Oral Appliance Therapy Research

Our goal is to provide efficient service and open lines of communication with the physicians and dentists we collaborate with to provide the best possible care for our patients.  See below for links to research articles that discuss Oral Appliance Therapy and its benefits. We encourage you to review them.  Please do not hesitate to call to discuss how we can serve you and your patients.

Oral Appliance Therapy vs. Continuous Positive Airway Pressure

Barnes MR, et al., Efficacy of Positive Airway Pressure and Oral Appliance in Mild to Moderate Obstructive Sleep Apnea, AJRCCM 2004; 170: 656-664.

Vanderveken OM, et al., Oral Appliance Therapy versus Nasal Continuous Positive Airway Pressure in Obstructive Sleep Apnea: A Randomized, Placebo-Controlled Trial, Respiration 2011; 81: 411-419.

Phillips CL, et al., Health Outcomes of Continuous Positive Airway Pressure versus Oral Appliance Treatment for Obstructive Sleep Apnea, AJRCCM 2013; 187 (8): 879-887.

Gagnadoux F., et al., Titrated Mandibular Advancement versus Positive Airway Pressure for Sleep Apnea, European Respiratory Journal 2009; 34(4): 914-20.

  • The results of this study support a successfully titrated mandibular advancement device as an effective treatment for significantly reducing the sleep apnea-hypopnea index in patients with mild to severe obstructive sleep apnea.
  • http://erj.ersjournals.com/content/34/4/914.long

Custom-fitted Dental Oral Appliances vs. Prefabricated Oral Appliances

Lettieri CJ, et al., Comparison of Adjustable and Fixed Oral Appliances for the Treatment of Obstructive Sleep Apnea, Journal of Clinical Sleep Medicine 2011; 7(5): 439-445.

Vanderveken OM, et al., Comparison of a Custom-made and Thermoplastic Oral Appliance for the Treatment of Mild Sleep Apnea, AJRCCM 2008; 178: 197-202.


Health Benefits of Oral Appliance Therapy

Iftikhar IH, et al., Effect of Oral Appliances on Blood Pressure in Obstructive Sleep Apnea: A Systematic Review and Meta-analysis, Journal of Clinical Sleep Medicine 2013; 9(2): 165-174.

Anandam A, et al., Cardiovascular Mortality in Obstructive Sleep Apnea Treated with Continuous Positive Airway Pressure or Oral Appliance: An Observational Study, Respirology 2013; 18(8): 1184-90.

Tegelberg A, et al., Improved Cognitive Functions after Treatment with an Oral Appliance in Obstructive Sleep Apnea, Nature and Science of Sleep 2012; 4: 89-96.

  • This study shows that, after only six months of treatment, oral appliance therapy can significantly improve daytime sleepiness and cognitive functions, specifically alertness and focus, of patients with mild to several obstructive sleep apnea.
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3630975/


Dental Sleep Medicine Practice Parameters

Ramar K, et al., Clinical Practice Guideline for the Treatment of Obstructive Sleep Apnea and Snoring with Oral Appliance Therapy: An Update for 2015, Journal of Dental Sleep Medicine 2015; 2(3): 71-125.

    • This research establishes oral appliance therapy as an effective alternative treatment option for patients with obstructive sleep apnea (OSA) and dentist-physician collaboration as necessary to achieve successful OSA treatment with oral appliance therapy.
    • https://www.ncbi.nlm.nih.gov/p...


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